Make sure it looks something like this:

# Do not remove the following line, or various programs
# that require network functionality will fail.
127.0.0.1       yourhostname localhost.localdomain   localhost
::1             yourhostname localhost6.localdomain6 localhost6
127.0.0.1       wpdev
127.0.0.1       wordpress1
127.0.0.1       wordpress2

]# cd /var/www/html; mkdir -p wpdev wordpress1 wordpress2

]# yum install httpd mysql-server php

For instructions on setting up MySQL go Here
Add these lines to the bottom of your httpd.conf located in: /etc/httpd/conf/httpd.conf

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NameVirtualHost *:80

<VirtualHost *:80>
    ServerAdmin webmaster@localhost
    DocumentRoot /var/www/html/wpdev
    ServerName wpdev
    ErrorLog logs/wpdev-error_log
    CustomLog logs/wpdev-access_log common
<Directory /var/www/html/wpdev>
    AllowOverride All
</Directory>
</VirtualHost>

<VirtualHost *:80>
    ServerAdmin webmaster@localhost
    DocumentRoot /var/www/html/wordpress1
    ServerName wordpress1
    ErrorLog logs/wordpress1-error_log
    CustomLog logs/wordpress1-access_log common
<Directory /var/www/html/wordpress1>
    AllowOverride All
</Directory>
</VirtualHost>
NameVirtualHost *:80

<VirtualHost *:80>
    ServerAdmin webmaster@localhost
    DocumentRoot /var/www/html/wordpress2
    ServerName wordpress2
    ErrorLog logs/wordpress2-error_log
    CustomLog logs/wordpress2-access_log common
<Directory /var/www/html/wordpress2>
    AllowOverride All
</Directory>
</VirtualHost>

]# mysql -p
Enter password:
mysql> CREATE DATABASE wordpress1;
mysql> GRANT ALL PRIVILEGES ON wordpress1.* TO 'you'@'localhost' IDENTIFIED BY 'yourpass';
mysql> FLUSH PRIVILEGES;
mysql> QUIT;

]# cd /var/www/html/wordpress1; unzip latest.zip; mv wp-config-sample.php wp-config.php
]# vi wp-config.php

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// ** MySQL settings - You can get this info from your web host ** //

/** The name of the database for WordPress */
define('DB_NAME', 'wordpress1');

/** MySQL database username */
define('DB_USER', 'you')

/** MySQL database password */
define('DB_PASSWORD', 'yourpass');

/** MySQL hostname */
define('DB_HOST', 'localhost');
define('AUTH_KEY',         'put your unique phrase here');
define('SECURE_AUTH_KEY',  'put your unique phrase here');
define('LOGGED_IN_KEY',    'put your unique phrase here');
define('NONCE_KEY',        'put your unique phrase here');
define('AUTH_SALT',        'put your unique phrase here');
define('SECURE_AUTH_SALT', 'put your unique phrase here');
define('LOGGED_IN_SALT',   'put your unique phrase here');
define('NONCE_SALT',       'put your unique phrase here');

Note: DO NOT USE THE SALTS IN THE EXAMPLE BELOW
Get a new set generated here: https://api.wordpress.org/secret-key/1.1/salt/

Example:
define('AUTH_KEY',         'v6liRDKI#vhN.{kB2M(u:}M^I][}f{,(0TzlVY^pWc.b;eO=/8l}8cD%1=X{mqm^');
define('SECURE_AUTH_KEY',  '=b}=YB^5G0>b|F0!9N`]F8Djvv({</IQHhG|R*Fa68{Op!@EudNaQb0[#@nr=?Q]');
define('LOGGED_IN_KEY',    'U5Aab1Sxf6VJ+PkJ<0Ty+.n8S9j|-MaSou6Hr$:y|F0Uq7GIofYmKzjz*=SLg=#)');
define('NONCE_KEY',        'Nj;FkNp-F+-.Du!:.d;r/^.&<Rw 8LV^0%A~A=dqQ5taS}+Z9ddd1d.|bO@4y%/9');
define('AUTH_SALT',        'M.OZPT;bK%wya&RT(`/a9_Eg-.n_Lv7{[AUio?LUx aI;J${D}t6H6F|9-wd.}@1');
define('SECURE_AUTH_SALT', 'A&&I^a}SGLEsw0+]_o}AYH(A2Y/G1jSTq2Cg~>%.g]}&YK]BbBq?&e:+N rWJ(_g');
define('LOGGED_IN_SALT',   'A4kIk[}0=Dra{y2/DU<w}oYvI+A:W0{Lx)nMF?3-Jp~kR+|{Eax00&ddK_[AMU<-');
define('NONCE_SALT',       '#9C{^mXT0@Ik(RQ<TYGtGLV!U|DkC)uKtHA}n@TkC|FjUc*s`xKiN~}ree}5lGe^');

]# service mysqld restart; service httpd restart

(This step allows you to run 1-click automatic core/theme/plugin updates from within your admin panel without being prompted for a password or ftp credentials) Security tip: DO NOT DO THIS ON PRODUCTION SERVERS
]# chown -Rf apache:apache /var/www/html

Next, open a web browser and go to http://wordpress1

You should be presented with the default WordPress install page.

You can repeat this for as many isolated instances as you want on your laptop or desktop Linux workstation.